Celebrex (Celecoxib) additional information

Celebrex, common uses

Celebrex, directions

Celebrex is indicated for relief of the signs and symptoms of osteoarthritis. Celebrex is also indicated for the relief of the signs and symptoms of rheumatoid arthritis in adults.

The lowest dose of Celebrex should be sought for and for relief of the signs and symptoms of osteoarthritis the recommended oral dose is 200 mg. per day administered as a single dose or as 100 mg. twice per day.

For relief of the signs and symptoms of rheumatoid arthritis the recommended oral dose is 100 to 200 mg. twice per day.

If you miss a dose, take it as soon as remembered if it is within an hour or so. If you do not remember until later, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Celebrex, precautions

NSAIDs should be used with extreme caution by individuals with a prior history of ulcer disease or gastrointestinal bleeding. Most spontaneous reports of fatal GI events are in elderly or debilitated individuals. To minimize the potential risk for an adverse GI event, the lowest effective dose should be used for the shortest possible duration. For high risk patients, alternate therapies that do not involve NSAIDs should be considered.

In late pregnancy Celebrex should be avoided because celecoxib may cause premature closure of the ductus arteriosus.

The pharmacological activity of Celebrex in reducing inflammation, and possibly fever, may diminish the utility of these diagnostic signs in detecting infectious complications of presumed noninfectious, painful conditions.

If clinical signs and symptoms consistent with liver disease develop, or if systemic manifestations occur (e.g., eosinophilia, rash, etc.), Celebrex should be discontinued.

Long term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Individuals at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly.

Discontinuation of NSAID therapy is usually followed by recovery to the pretreatment state. Clinical trials with Celebrex have shown renal effects similar to those observed with comparator NSAIDs.

Caution should be used when initiating treatment with Celebrex in individuals with considerable dehydration. It is advisable to rehydrate first and then start therapy with Celebrex. Caution is also recommended in individuals with pre-existing kidney disease.

There are no studies of the effects of Celebrex in pregnant women. Celebrex should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Celebrex, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Caution should be used when administering Celebrex with warfarin since these individuals are at increased risk of bleeding complications.

Celebrex, possible side effects

If you notice other effects not listed above, contact your doctor.

Celebrex, overdose

Symptoms following acute NSAID overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.

Celebrex, additional information

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