Sinemet (Carbidopa/Levodopa)
Sinemet
Sinemet tablets. When you buy Sinemet online, each tablet contains 100 mg levodopa and 25 mg carbidopa, or 250 mg levodopa and 25 mg carbidopa. Sinemet comes in packs of 120 tablets and is manufactured Bristol-Myers Squibb.Sinemet directions
Sinemet is a combination of carbidopa, an inhibitor of the aromatic amino-acid decarboxylase enzyme and levodopa, the metabolic precursor of dopamine.Sinemet is indicated in the treatment of the symptoms of idiopathic Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and manganese intoxication.
Sinemet is indicated in these conditions to permit the administration of lower doses of levodopa with reduced nausea and vomiting, with more rapid dosage titration, with a somewhat smoother response, and with supplemental pyridoxine (vitamin B6).
The optimum daily dosage of carbidopa-levodopa must be determined by careful titration in each patient.
Dosage is best initiated with one tablet of carbidopa-levodopa 25 mg/100 mg three or four times a day. Dosage may be increased by one tablet every day or every other day, as necessary, until a dosage of eight tablets of carbidopa-levodopa 25 mg/100 mg a day is reached.
If being treated with levodopa only, it must be discontinued at least eight hours before starting carbidopa-levodopa combination. A daily dosage of Sinemet should be chosen that will provide approximately 25 percent of the previous levodopa dosage. Patients who are taking less than 1500 mg of levodopa a day should be started on one tablet of carbidopa-levodopa 25 mg/100 mg three or four times a day. The suggested starting dosage for most patients taking more than 1500 mg of levodopa is one tablet of carbidopa-levodopa 25 mg/250 mg three or four times a day.
The most common serious adverse reactions occurring with Sinemet are choreiform, dystonic, and other involuntary movements. Other serious adverse reactions are mental changes including paranoid ideation and psychotic episodes, depression with or without development of suicidal tendencies, and dementia.
When you buy Sinemet, the order will be shipped using the postal services.