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Tag: CYP3A4 inhibition

Colchicine and Macrolides: How Drug Interactions Can Turn Life-Saving Medications Deadly
  • 31 Jan 2026
  • Elliot Buzzetti

Colchicine and Macrolides: How Drug Interactions Can Turn Life-Saving Medications Deadly

Colchicine and macrolides like clarithromycin can cause life-threatening toxicity when taken together due to CYP3A4 and P-gp inhibition. Learn why azithromycin is safer, who's at risk, and what to do if you're on both.

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